A recent clinical trial published in The New England Journal of Medicine explored a promising therapy called zimislecel, which has shown potential in restoring insulin production in individuals with Type 1 diabetes.
Zimislecel is an allogeneic stem cell-derived islet cell therapy, a new approach aimed at treating Type 1 diabetes.
Islet Cells: The therapy involves islet cells—clusters of cells in the pancreas that produce hormones, including insulin. In individuals with Type 1 diabetes, the immune system destroys the beta cells in the pancreas, leading to an inability to produce insulin.
Stem Cell-Derived Islets: Zimislecel is created by growing islet cells from pluripotent stem cells in the laboratory. These cells are then matured into functioning islets capable of producing insulin.
Infusion into the Liver: The lab-grown islet cells are infused into the hepatic portal vein, which leads to the liver. This method allows the cells to take root, survive, and ideally start producing insulin.
Restoration of Insulin Production: The goal of this therapy is to restore glucose-responsive insulin production in the body, enabling individuals to regulate their blood sugar levels naturally.
The infused islet cells began producing insulin again, which improved blood sugar control, and helped prevent dangerous blood sugar lows (hypoglycemia).
In many cases, the therapy eliminated the need for daily insulin injections, marking a significant improvement in diabetes management.
Type 1 diabetes is a chronic condition where the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. This results in very little or no insulin production, making it difficult to regulate blood glucose levels.
Polyuria (excessive urination)
Polydipsia (extreme thirst)
Constant hunger
Weight loss
Vision changes
Fatigue
The trial of zimislecel therapy marks a significant milestone in the ongoing search for a cure or long-term treatment for Type 1 diabetes. By utilizing stem cells to restore pancreatic function, this therapy could revolutionize the way we treat diabetes in the future.
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In every Lecture. Director Sir will provide conceptual understanding with around 800 Mindmaps.
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