Daily News Analysis

DengiAll

stylish_lining

India's progress with the DengiAll vaccine is a major development in the global fight against dengue, and it highlights the country's growing capability in the field of indigenous vaccine development.

DengiAll: The Indigenous Tetravalent Dengue Vaccine

Development and Collaboration:

  • Developer: The vaccine is developed by Panacea Biotec Limited under a licensing agreement with the National Institutes of Health (NIH), USA.

  • Composition: DengiAll is a tetravalent vaccine, meaning it targets all four types of dengue virus (DENV). It uses a weakened form of the four virus subtypes, with the same virus composition as the vaccine developed by the NIH but with different inactive ingredients.

Clinical Trial Phases:

  • Phase I & II Trials: Initial trials conducted in India showed that the vaccine elicited a balanced and robust immune response against all four types of dengue. The vaccine was also found to be safe and well-tolerated in participants.

    Phase III Trial: India has recently reached the 50% enrolment mark for the Phase III clinical trial, which aims to test the efficacy, immunogenicity, and safety of DengiAll. The trial is being carried out in collaboration with several institutes, including those under the Indian Council of Medical Research (ICMR).

ICMR Institutes Involved:

  • The ICMR-National Institute of Translational Virology (NITVAR) and ICMR-National AIDS Research Institute (NARI) are playing key roles in trial coordination.

    These institutes will ensure that the vaccine's performance and safety are rigorously tested across diverse populations.

Key Facts About Dengue

What is Dengue?

  • Dengue is a mosquito-borne viral infection that occurs mostly in tropical and subtropical regions, particularly in urban and semi-urban areas.

Transmission:

  • The disease is transmitted to humans via the bite of infected Aedes mosquitoes carrying one of the four types of dengue virus (DENV).

    Dengue is not contagious from person to person, except in rare cases where it is passed from a pregnant person to their child.

Symptoms:

  • Common symptoms include:

    • High fever

    • Headache

    • Body aches

    • Nausea

    • Rash

    Dengue Hemorrhagic Fever (DHF): A small proportion of patients may experience severe symptoms leading to Dengue Hemorrhagic Fever, which is life-threatening.

Treatment:

  • There is no specific antiviral treatment for dengue.

    Supportive care is provided to manage symptoms, particularly focusing on pain relief and fever reduction.

Significance of DengiAll's Development

  1. Indigenous Vaccine: This marks a significant step towards self-reliance in vaccine production, with India taking a leading role in the development of a tetravalent dengue vaccine.

  2. Global Health Impact: Dengue is a major health concern in many parts of the world. A successful vaccine can greatly reduce the burden of the disease, especially in endemic regions.

  3. Efforts in Vaccine Development: This project reflects India's ability to develop cutting-edge medical technology in collaboration with global research bodies like NIH, making it an important milestone for Indian scientific innovation.

Conclusion

The DengiAll vaccine trial's success could be a game-changer in the global fight against dengue. The Phase III trial is crucial for determining whether the vaccine can provide long-term protection against all four dengue virus types. India's indigenous capabilities in vaccine development are growing, and DengiAll represents a significant leap toward reducing the public health threat posed by dengue.


 

Collegium System of Judicial Appointments in India

The Collegium system refers to India's judicial process for appointing and transferring judges to the Supreme Court and High Courts. While the system plays a crucial role in maintaining judici
Share It

Sea-Level Rise

Coral micro-atolls are essential natural recorders of sea-level rise (SLR), offering valuable insights into past and present oceanic changes. These disk-shaped coral colonies provide a unique meth
Share It

India’s Strategy in the Indian Ocean

Why the Indian Ocean Matters: Strategic Importance: The Indian Ocean is the third-largest ocean in the world, hosting 1/3rd of the global population and acting as a crucial maritime trade
Share It

ASEAN Centrality

Why in the News? ASEAN’s central role in the Indo-Pacific is increasingly under strain due to rising great-power rivalry, shifting global trade dynamics, and the evolving regional order.
Share It

2025 SCO Summit in Tianjin

The 25th Shanghai Cooperation Organization (SCO) Summit held in Tianjin, China in 2025 brought together the heads of state of member countries to address a broad spectrum of issues, including secu
Share It

India’s Carbon Emissions Trading System

The Ministry of Environment, Forest and Climate Change (MoEFCC) has made a significant stride in India’s climate strategy by setting up the National Designated Authority (NDA) to implement a
Share It

Jan Vishwas (Amendment of Provisions) Bill, 2025

The Jan Vishwas (Amendment of Provisions) Bill, 2025 was introduced in the Lok Sabha to amend various provisions across several central acts with the goal of decriminalizing offences and promoting
Share It

Fair and Representative Global Order

India’s External Affairs Minister recently called for a fair and representative global order during the BIMSTEC Traditional Music Festival. The statement highlights the growing need for reforms
Share It

India's First EMI-Based Credit Card

Recently, Unity Small Finance Bank and BharatPe launched India's first EMI-driven credit card on the RuPay network. This innovative product allows users to pay for their purchases in full or c
Share It

Civil Society Organizations (CSOs)

Why in News? Civil Society Organizations (CSOs) have gained prominence for their vital role in promoting collective action, protecting rights, and filling gaps in governance. They serve as cata
Share It

Newsletter Subscription


ACQ IAS
ACQ IAS